Prince Andrew relinquishes his designation as the Duke.
The royal is surrendering his titles, among them the York's Duke, he has announced in a individual message.
He has been under increasing pressure over his links with sex offender the financier, with demands for the royal household to take action against him.
That now appears to have resulted in the prince deciding to voluntarily hand back his honors and to relinquish participation of the Order of the Garter.
In his statement he said he continued to "strongly deny the claims against me".
"In consultation with the sovereign, and my direct and wider family, we have concluded the ongoing accusations about me distract from the work of His Majesty and the monarchy," said a announcement from him.
"I have opted, as I always have, to put my duty to my kin and land first.
"I stand by my choice five years ago to withdraw from royal engagements.
"With the monarch's consent, we feel I must now go a additional measure. I will therefore no longer employ my designation or the awards which have been bestowed on me. As I have said before, I vigorously deny the allegations against me."
The royal has been involved in a number of scandals, including a lawsuit he ended with an accuser, doubts about his economic affairs and his association with an accused intelligence operative.
He will stay a prince - but will discontinue to be the York's Duke, a designation granted from his the late Queen, the Queen Elizabeth II.
Andrew had already ceased to be a "active member" and had forfeited the use of his royal style and no longer participated at public engagements. His role now will be even more reduced.
His former spouse will be known as Sarah Ferguson and no longer York's Duchess, but their children will persist to have the title of princess.
Prince Andrew has encountered strong scrutiny over his connections with notorious figure Epstein, more in recent times featuring inquiries about when he had actually severed contact.
In his media discussion, he had said that he had cut off all ties with Epstein after they had been seen together in the city in December 2010.
But correspondence sent in early 2011 later surfaced implying that the prince had privately continued in touch with the financier, such as exchanging a message: "Stay in contact and we'll meet again soon!"
There had been increasing frustration in Buckingham Palace at the issues that continued to envelop the figure.
In the coming days a late publication by Virginia Giuffre will be released which is expected to bring additional focus on the royal's involvement with Virginia Giuffre and Epstein.